THIS study was stimulated by the classic discoveries of the association of chromosomal aberrations with several syndromes of multiple congenital anomalies 1–5 followed by a rapid expansion of research ...

Genomic instability denotes a heightened tendency for genetic alterations and is recognised as a fundamental hallmark of cancer. Disruption of DNA replication fidelity or repair mechanisms leads to ...

Chromosomal aberrations constitute a significant cause of male infertility, accounting for up to 15 per cent of cases with severe spermatogenic failure. Structural rearrangements such as ...

All age group capable of reproduction are at risk of this, but however, research has shown that the risk of chromosomal abnormality increase with maternal age. That is, the chances of having a child ...

Data of a large group of patients younger than 18 years treated according to study AML–Berlin-Frankfurt-Münster (BFM) 98 (n = 454), including their cytogenetics, were analyzed. Because the prognostic ...

Join us June 26 th at 8am PT, 11am ET as Dr. Laila El Khattabi and Dr. Alexander Hoischen discuss Next-Generation Cytogenetics: international, multi-center study of chromosomal aberrations in ...