The condensin complex is essential for correct packaging and segregation of chromosomes during mitosis and meiosis in all eukaryotes. To date, the genome-wide location and the nature of ...

Cohesin contributes to intrachromosomal loops that regulate metazoan gene expression by constraining interactions between promoter and enhancer elements. These structures can be subject to regulation ...

Scientists have discovered how condensin keeps chromosome arms folded and easy-to-transport during cell division, potentially acting as a cord-stopper. As any rock-climber knows, trailing a long ...

Scientists have identified how a specific variant of a key protein complex found in human cells called condensin can reorganize a cell's genetic architecture in such a way as to promote senescence, ...

Advances in our understanding of basic biological processes and human disease owe much to the groundbreaking research of scientists at the Chromosome Dynamics Laboratory at RIKEN Advanced Science ...

Remarkably, living cells are able to package a jumble of DNA over two meters in length into tidy, tiny chromosomes while preparing for cell division. However, scientists have been puzzled for decades ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

Frog egg extracts have yielded insights into the intricacies of what happens to chromosomes when our cells divide Experiments using extracts from African clawed frog eggs have revealed how a key ...

The first theoretical model of condensin, a molecular machine involved in packing and unpacking chromosomes, accurately reproduces all known experiments with just two parameters. To scrunch a ...

During quiescence, cells cease to proliferate and enter a state of dormancy where they are resistant to stressors and can survive long-term. In quiescent cells, global gene expression is decreased by ...

Stress can make you wish life had a pause button. Single-celled organisms like yeast actually have this option. Faced with a lack of food or other stressors, baker’s yeast can enter a “paused,” energy ...