Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...
Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...
A new mouse study found that unrepaired DNA-protein crosslinks activate inflammatory signaling pathways that trigger early aging disorders.
Notably, inhibition of cGAS-STING from early development rescued mice from developmental lethality and premature aging caused ...
If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...
For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a ...
“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...
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