Researchers at GlaxoSmithKline report a greener and lower-cost route to chiral fluorolactams that is suitable for scale up. The incorporation of fluorine into APIs continues to be a key approach to ...

Fluorination and surface modification of polymers have emerged as pivotal techniques in enhancing the chemical, thermal and mechanical properties of polymeric materials. Through the incorporation of ...

Fluorination can significantly impact the bioavailability of drug substances, however, safer fluorinating reagents and access to GMP fluorination capabilities remain challenges. Due to its high ...

(Nanowerk News) Researchers from Tohoku University and collaborators have developed a weak fluorination strategy to address the zero-bandgap limitation of graphene. The findings are published in ...

A coalition of food safety and agricultural groups are asking the Environmental Protection Agency to ban the use of fluorinated high density polyethylene and polypropylene containers in pesticide ...

Cytochrome P450 enzymes selectively oxidize relatively unactivated sites in a range of model drug-like substrates in vitro. The hydroxylated products can be transformed into selectively fluorinated ...

In a study published in Applied Physics Letters, researchers at Tohoku University introduced a mild fluorination method to address graphene's zero-bandgap limitation. Characterization of the Gr and ...

Tasked with improving the biological profile of drug candidates, medicinal chemists treasure reactions that easily slip a fluorine atom onto a molecule. That’s because the addition of this little ...

Fluorination of therapeutic agents is a widely used strategy in the pharmaceutical industry. It improves a drug’s molecular properties, such as drug-target interactions, bioavailability, and ...

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We collaborate with the world's leading lawyers to deliver news tailored for you. Sign Up for any (or all) of our 25+ Newsletters. Some states have laws and ethical rules regarding solicitation and ...

A novel chemoenzymatic method can add fluorine atoms to natural compounds. The method uses an enzyme that acts as a gatekeeper for precursors and designs a pinch of precursor tolerance to create a ...