Protecting the headquarters of genetic information within the cell was a mechanism that provided an evolutionary advantage millions of years ago and established the nucleus as the principal organelle ...

Mutational profiling of true single circulating tumor cells (sCTC) in metastatic lung cancer to determine genomic heterogeneity and drug-resistance signatures. Effects of different immune ...

To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long ...

How soluble proteins get into the cell nucleus is known in great detail, but how membrane proteins make it into the inner nuclear membrane has long been an enigma. The two processes in fact turn out ...

How do expanded hexanucleotide repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis and frontotemporal dementia? They give rise to aberrant dipeptide repeat proteins, but even though these ...