Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients. Their ...

32 P-label is introduced by incoming dGT 32 P molecule. The arrows indicate the sites of enzymatic hydrolysis. The bases of the template DNA strand are designated as clear boxes, and the bases in the ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...

Cells have evolved sophisticated mechanisms of DNA damage response and repair to minimize mutations that lead to genomic instability and cancer development. A variety of nucleases are critical DNA ...