Leydig cell lineage originates from multipotent mesenchymal precursors in the interstitial compartment of the testis. Development proceeds through distinct stages: undifferentiated stem Leydig cells ...

Testosterone synthesis in testicular Leydig cells is orchestrated by a tightly regulated sequence of signalling events, cholesterol trafficking and enzymatic conversions. Upon luteinizing hormone (LH) ...

The effects of cannabis on the hormonal system and male fertility remain controversial within the scientific community. A study conducted by the University of Geneva (UNIGE), in collaboration with the ...

Direct assessment of Leydig cell function in childhood cancer survivors has been limited. The objectives of this study were to describe the prevalence of and risk factors for Leydig cell failure (LCF) ...