A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...

Pain represents the cardinal symptom of osteoarthritis, yet its intensity, quality, and impact vary dramatically among ...

"One region in the thoracolumbar spinal cord was shown to relay noxious information into brainstem pain-related circuits, while the other spinal region in the lumbosacral spinal cord carried a broader ...

René Descartes gave a colorful description of the mechanism of pain in the 17th Century: "Particles" of fire set in motion a spot on the skin of the foot, and by means of a "delicate thread" they open ...

For the first time, scientists have generated a functional neural pathway for sensing pain in a dish. This could help unravel mechanisms of pain disorders. “This is important groundbreaking work,” ...

New research into the mechanism of the placebo effect sheds light on the brain circuitry involved in pain relief. The study, conducted by scientists at the University of North Carolina (UNC), Stanford ...

Chronic pain is no joke. It can upend your life, steal away your ability to live in the moment and force you to find gumption within yourself you didn’t know existed. It’s something that an estimated ...

Researchers at UC Santa Barbara identified a pain pathway in fruit flies that reduces the sensation of pain from heat. The researchers discovered that just a single neuron on each side of the animal’s ...