The formation and patterning of mesoderm during mammalian gastrulation require the activity of Nodal, a secreted mesoderm-inducing factor of the transforming growth factor-β (TGF-β) family. Here we ...

Using staged embryos, researchers report a genomic analysis of mouse gastrulation and organogenesis. The post-implantation period is a dramatic one for the mouse embryo. Over the course of about 3 ...

Toward the goal of generating high-quality embryo models in vitro, this study establishes a stepwise protocol to derive trophectoderm-like cells from mouse extended pluripotent stem (EPS) cells. These ...

Prior to gastrulation the mouse embryo exists as a symmetrical cylinder consisting of three tissue layers. Positioning of the future anterior-posterior axis of the embryo occurs through coordinated ...

A team of biologists, physicists and mathematical modellers have studied the genetic activity of over 100,000 embryonic cells to establish the molecular blueprint of mouse early embryo development.

With the construction of a building, one of the first steps before creating the upright structure is to set the foundations and the floorplan. Mammalian development is not so different. A ...

Alaniz Emig A, Williams MLK. Generation of Naïve Blastoderm Explants from Zebrafish Embryos. J Vis Exp. 2021 Jul 30;(173). doi: 10.3791/62797. PMID: 34398141. View article Williams ML, Solnica-Krezel ...

In a recent study published in the Cell journal, researchers showed that post-gastrulation synthetic embryos (sEmbryos) could be synthesized outside the uterus using mouse naïve embryonic stem cells ...

2014-present: Senior Research Scientist, Developmental Biology Program, Sloan Kettering Institute (lab of Kat Hadjantonakis) 2011–2014: Research Associate, Developmental Biology Program, Sloan ...