Ultrastructural analysis of cortical synaptic connectivity by electron microscopy has typically been limited to small volumes of tens of micrometres in extent 1,2,3,4,5,6,7. Similarly, connectivity ...

This is a preview. Log in through your library . Abstract Dendritic spines are sites of the vast majority of excitatory synaptic input to hippocampal CA1 pyramidal cells. Estrogen has been shown to ...

John P. Vessey, Lucia Schoderboeck, Ewald Gingl, Ettore Luzi, Julia Riefler, Francesca Di Leva, Daniela Karra, Sabine Thomas, Michael A. Kiebler, Paolo Macchi, Ruth Lehmann Proceedings of the National ...

In people with Alzheimer’s disease and other tauopathies, tau can accumulate at post-synapses in the dendrites of neurons. Could eliminating this tau temper neurodegeneration? In the May 26 Science ...

Scientists know that synaptic plasticity requires local protein production from translation of mRNAs in postsynaptic dendrites. However, local synthesis had not been clearly demonstrated on the other, ...

Last week we learned that blocking expression of the AMPA receptor GluR1 subunit in motor neurons reduces dendrite growth, leading to impaired motor function. This week, Zhou et al. begin to unravel ...