The structure and function of synapses are highly heterogeneous, even among synapses formed on single neuron 1,2,3. At the same time, pre- and postsynaptic structures and functions are well ...

Synaptic adhesion molecules such as neuroligin are involved in synapse formation, whereas ionotropic transmitter receptors mediate fast synaptic transmission. In mutant mice deficient in the glutamate ...

Depression is a common comorbidity of temporal lobe epilepsy and has highly negative impact on patients’ quality of life. We previously established that pilocarpine-induced status epilepticus (SE) in ...

A research team revealed in an animal study a previously unknown role of a presynaptic adhesion molecule to tell the new change by regulating postsynaptic NMDA-type receptor responses at excitatory ...

This is a preview. Log in through your library . Abstract Dendritic spines are sites of the vast majority of excitatory synaptic input to hippocampal CA1 pyramidal cells. Estrogen has been shown to ...

When the brain forms memories or learns a new task, it encodes the new information by tuning connections between neurons. Now neuroscientists have discovered a novel mechanism that contributes to the ...

A new study has revealed how tau – a microtubule-binding protein that is implicated in Alzheimer’s disease – weakens transmission across synapses in the brains of mice When injected into presynaptic ...