Dual brakes on T-cells: New targets found to boost immunity in chronic infections

Northwestern Medicine scientists have identified the cellular mechanisms that cause immune cells to differentiate and ...
GEN

Cell Surface Marker Profiling with Spectral Cytometry Optimizes CAR T Manufacturing

Not all patients respond well to chimeric antigen receptor (CAR) T cell therapies, which reprogram a patient’s own immune cells to recognize and attack cancer. A way to optimize these treatments is to ...
Phys.org

Lipid nanoparticles that engineer CAR T cells in vivo could unlock access for millions of autoimmune patients

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...
News Medical

Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by ...