Ras proteins are small GTPases that function as molecular switches governing growth, morphogenesis and stress responses in eukaryotic organisms. In pathogenic fungi, Ras-mediated signalling integrates ...
RAS–MAPK pathway inhibitors are limited by pathway reactivation and toxicity. A study now introduces IK-595, a MEK–RAF molecular glue that stabilizes MEK in an inactive complex with RAF isoforms, ...
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