Baylor College of Medicine

Retrovirus Vector

Retroviruses are a sub-category of oncoviruses that include the lentiviruses. Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is ...
The New England Journal of Medicine

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus–based γ-retrovirus vector expressing interleukin-2 receptor ...
Nature

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

Retroviruses insert their genes in a semirandom manner into host chromosomes, 18 and it is thought that retroviruses may integrate preferentially into transcriptionally active sites. 19 There is ...
Nature

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation

A recent clinical trial in two adult X-CGD patients incorporated partially ablative busulfan conditioning before the infusion of autologous CD34+ cells transduced with the SF71gp91 phox γ-retroviral ...