The bacterial second messenger cyclic diguanylate (c-di-GMP) regulates a wide range of cellular functions from biofilm formation to growth and survival. Targeting a second-messenger network is ...
In the eukaryotic chemosensory signaling circuit, attractant signals sensed by cell-surface receptors are amplified by a positive feedback loop at the leading edge of the cell. The feedback loop, in ...
The second messenger cyclic di-AMP (c-di-AMP) plays a pivotal role in bacterial physiology by regulating osmolyte transport, potassium uptake, cell wall integrity and the overall stress response.
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