There’s no doubt that large language models and generative AI tools have taken the world by storm. Their ability to create, ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...

Defining precisely where drugs engage their targets in vivo is essential for understanding efficacy and toxicity. However, mapping in vivo drug targets with spatial and cellular resolution remains ...

Discover how researchers are overcoming the limitations of the undruggable target in drug discovery using novel approaches ...

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...

One person's side effect could be another person's treatment if we expand our perspective on small molecule drug targets, according to a new study published November 5, 2025, in npj Precision Oncology ...

A Purdue University team has discovered a new therapeutic target for triple-negative breast cancer. The research, led by Kyle ...

When you take a drug, where in your body does it actually go? For most medications, scientists can make only educated guesses about the answer to this question. Traditional methods can measure the ...

This article and associated images are based on a poster originally authored by Adam Buckle, Julia Unsicker and Iain McWilliam and presented at ELRIG Drug Discovery 2025 in affiliation with Arrayjet ...