We thank Harold Pupko for raising several relevant points concerning our article.1 Valproate-induced hyperammonemic encephalopathy is a well- described phenomenon, but its precise incidence is unknown ...

Divalproex sodium 250mg, 500mg; ext-rel tabs. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have ...

Hyperammonemia is a condition in which a person has elevated levels of ammonia. Typical symptoms include irritability, vomiting, confusion, and other effects of swelling in the brain. People of all ...

Saleh Alqahtani and colleagues have provided a welcome reminder that hyperammonemia is a common side effect of valproate therapy.1 However, I am not convinced that hyperammonemia is a benign ...