Dec 15, 2025 · In this issue of the JCI, Miao et al. demonstrated that MCC tumor survival requires neuroendocrine-lineage transcription factors, which are recruited to superenhancers (SEs) with the …

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Volume 135, Issue 24December 1, 2025

Dec 15, 2025 · In this issue of the JCI, Miao et al. demonstrated that MCC tumor survival requires neuroendocrine-lineage transcription factors, which are recruited to superenhancers (SEs) with the …

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Nov 15, 2024 · Kurihara C, et al. Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment. JCI Insight. …

JCI Insight is a peer-reviewed journal dedicated to biomedical research, ranging from preclinical to clinical studies. JCI Insight is a Gold Open Access journal that has a 2023 Impact Factor of 6.3.

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Nguyen et al. report that palmitate triggers ROS-induced Ca2+ overload and mTORC1 activation at the lysosomal membrane, resulting in autophagy defects. Restoring perilysosomal Ca2+ homeostasis …